pentobarbital will lower the level or impact of theophylline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
Drugs which have constraints apart from prior authorization, amount boundaries, and phase therapy related to Each individual prescription.
pentobarbital will reduce the extent or result of dienogest/estradiol valerate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Women of all ages mustn't select estradiol valerate/dienogest as their contraceptive whilst applying sturdy CYP3A4 inducers because of opportunity lower in contraceptive efficacy.
pentobarbital will minimize the level or impact of ixabepilone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
pentobarbital will decrease the extent or impact of meloxicam by affecting hepatic enzyme CYP2C9/ten metabolism. Minor/Importance Unfamiliar.
CYP3A4 inducers may perhaps raise the development on the neurotoxic/nephrotoxic ifosfamide metabolite, chloroacetaldehyde. Closely check patients getting ifosfamide with CYP3A4 inducers for toxicities and take into consideration dose adjustment.
Contraindicated (1)pentobarbital will lower the level or influence of roflumilast by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital raises amounts of vortioxetine by escalating metabolism. Modify Therapy/Observe Intently. Take into account raising the vortioxetine dose when coadministered with robust CYP inducers for >14 days; to not exceed 3 instances original vortioxetine dose.
This drug may perhaps enhance the metabolism of estradiol when administered concurrently; clients on oral contraceptives are getting to be Expecting when concurrently dealt with with antiepileptic medications; propose an alternate contraceptive approach to Ladies having this drug
pentobarbital will lower the extent or outcome of conjugated estrogens by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
pentobarbital will lessen the level or effect of bedaquiline by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Avoid coadministration of bedaquiline with powerful CYP3A4 inducers because of probable for lowered therapeutic outcome
Withdrawal symptoms may well take place from abrupt cessation soon after prolonged use in the dependent man or woman and will result in delirium, convulsions, And maybe Demise; barbiturates ought to be withdrawn step by step from any individual recognized to generally be getting excessive read more dosage about extensive periods of time
pentobarbital will lessen the extent or result of vinblastine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unidentified.
pentobarbital will decrease the extent or outcome of abemaciclib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of abemaciclib with strong CYP3A4 inducers cuts down plasma concentration of abemaciclib and its metabolites.